Her first novel, Compromising Positions, was published in 1978. It was chosen as a main selection of the Book of the Month Club and was, like all of her subsequent novels, a New York Times bestseller. Her fiction has been translated into thirty different languages all over the world. In 1985, she adapted her own novel for the screenplay of the film Compromising Positions, which starred Susan Sarandon and Raul Julia. She wrote and co-produced Touchstone Pictures’ Hello Again, a 1987 comedy starring Shelley Long and Judith Ivey. In addition to writing books, essays, and screenplays, Isaacs has reviewed books for The New York Times, the Los Angeles Times, The Washington Post, and Newsday. Issacs has also written about politics and First Amendment issues.