I could deal with them before having pink floyd, but the defense helps. I don’t think stopping to heal is worth the trouble sometimes, so you might as well go all out. The main thing, as already pointed out, is to have plenty of ego. Also don’t neglect Sexiness, as you don’t want to spend time recharging it. When going about my business pwning, my set up is:

Ego 5095

Sexiness 760

Offense 102

Defense 61

Luck 23

Frugality 8

Charisma 58

Upkeep 4

Plus if you go for the stuff you get in Ep 2 as well, then you should be having an even easier time. Compared to the toughest in Episode One, these only seem worse because they can hit harder than consumables can heal, but realistically our stats supercede that.