Sucking up to the NPCs will occasionally net you a reward, but being male reproductive organs to them has no negative consequences.

Currently it seems that it’s impossible to miss out on a mission or a flezz reward, though. If you try refusing to do the last mission, it eventually just gives you the single option of saying “You know what, **** it, I realize that the only way to progress the game is to stop being such a woman's genitals. I’ll do it!”

So, say and do whatever you want, there’s no downside to it – yet.