Let’s see…

-Jazz Jackrabbit 2: Toaster and powered-up Blaster with rapid-fire. NOTHING SURVIVES.

-Ratchet and Clank: I haven’t played all the games fully yet, but I liked the Megarocket Cannon from 2 and it’s little brother, the Decimator from 3.

-Golden Sun The Lost Age: Sol Blade. Full Stop. Works best if you have a lot of Luck-increasing items.

-Persona 4: Yo****sune. Not really a weapon, but a Persona, it can learn Power Charge (doubles the power of your next attack) and Hbumou Tobi (does eight weak hits worth of damage to all enemies). Combine the two and you get something potentially game-breaking. Oh, and Yoshi comes with immunity to physical attacks, which is ALWAYS nice.

-ForumWarz: Pink Floyd. Now if they only had a similar item, only based off of Micheal Jackson…That one would just BREAK the game with its sheer awesomeness. RIP, MJ.

That’s all I can think of now, lol.